Increasing Infusion Times of Hyperpolarized [1-¹³C]Pyruvate in a Mouse Brain Maintain Lactate Generation and Approach Pseudo-Steady State Metabolism.

While our 1D dynamic data of the mouse head showed similar lactate AUC between the different infusion times (Figure 3B ), the 2D dynamic data of the mouse brain showed a trend toward increased effective metabolic conversion of pyruvate to lactate at longer infusion times (60 s; Figure 6H,I ), although lactate AUC values (Figure 6B–D ) were comparable.

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