Acyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake.

In contrast, multiple cohorts of male and female Acsl5 KO mice fed chow diet from weaning showed a trend toward lower body fat, with BW and LBM that were not different from WT ( Table 1B ); when normalized body fat data were pooled from all male and female chow-fed cohorts, KO mice showed a modest but significant 10% decrease (WT: 100% ± 47% [n = 144] vs KO: 90% ± 40% [n = 138], P < .05), confirming HTPS data.

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