Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions.

Aging Cell · 2026 · PMC12853144 · PMID 41607341

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

did not reach statistical significancep = 0.09so close (0.05 < p ≤ 0.1)

Despite graphical evidence that PAC and GrimAge2 may also be nonlinearly related to changes in BMI, these associations did not reach statistical significance ( p = 0.09 and p = 0.10, respectively).

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close to significanceno p-value reported

In addition, GrimAge2 was identified as being significantly nonlinearly associated with changes in BMI, whereas it was close to significance in the original analyses.

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