Barely Significant
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Autoantibodies as predictors for immune-related adverse events in checkpoint inhibition therapy of metastatic melanoma.

J Immunother Cancer · 2026 · PMC12853468 · PMID 41592893

1
hedged sentence
0.0770
closest p · 1.5× alpha
0.0770
boldest claim

The sentences

did not reach statistical significancep=0.077so close (0.05 < p ≤ 0.1)
In the ipi/nivo combination group, anti-RPLP2 was significantly associated with irAE risk (HR=1.63, p=0.010), while anti-KRT7 showed a similar trend that did not reach statistical significance (HR=1.27, p=0.077).

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