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SAMHD1 drives immunosuppression in non-small cell lung cancer by promoting macrophage infiltration and restricting oncolytic adenovirus replication.

J Immunother Cancer · 2026 · PMC12853542 · PMID 41611242

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OS results indicate that although OS did not reach statistical significance between high-SMD1 and low-SMD1 expression groups, a trend toward shorter OS in patients with high SMD1 expression ( figure 1D ).

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