An integrative algorithm combining HLA epitope registry, PIRCHE-T2, and PIRCHE-B outcomes to improve immunological risk stratification in kidney transplantation.

Front Immunol · 2025 · PMC12855065 · PMID 41624855

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

narrowly missed significancep = 0.052so close (0.05 < p ≤ 0.1)

Epregistry and PIRCHE-T2 showed significantly higher mismatch scores in the dnDSA + group compared to dnDSA - ( Figures 2A, B ), while PIRCHE-B showed a similar trend that narrowly missed significance ( Figure 2C , p = 0.052 ).

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did not reach statistical significanceno p-value reported

Interestingly, although HLA-A scores trended higher in the dnDSA + group, they did not reach statistical significance, suggesting potential variability in the peptide presentation landscape specific to that locus.

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