Although T3 tended to decrease the intrinsic activation of liver receptor homolog-1 (LRH-1, NR5A2) with low efficacy, this effect did not reach statistical significance (one-sided t-test against 0.1% DMSO control).
← all excerpts
The metabolic dysfunction-associated steatohepatitis (MASH) drug resmetirom exhibits broad nuclear receptor activity with minimal functional impact.
1
—
—