Virus-based IFNγ gene delivery and photodynamic therapy cooperate to remodel the tumor microenvironment and suppress breast cancer.

Mol Ther Oncol · 2026 · PMC12857546 · PMID 41624403

Europe PMC DOI

hedged sentences

0.0930

closest p · 1.9× alpha

0.0930

boldest claim

The sentences

did not reach statistical significancep = 0.093so close (0.05 < p ≤ 0.1)

PDT alone showed a 40.8% reduction in tumor burden while SFV/IFNγ alone showed a 40.5% reduction; however, this did not reach statistical significance ( p = 0.093 and 0.090, respectively).

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an increasing trendno p-value reported

Moreover, an increasing trend in the proportion of mature DCs (F4/80 – CD11c + MHC II high ) was observed following treatment with PDT, SFV/Luc, and SFV/IFNγ individually; however, this increase reached statistical significance only in the combined treatment groups, PDT + SFV/Luc ( p = 0.011) and PDT + SFV/IFNγ ( p = 0.0012), with the highest number of mature DCs in the PDT + SFV/IFNγ group.

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