Circulating cell-free mitochondrial DNA as a candidate marker of hyperinflammation and immune activation in pre-adolescents, adolescents and young adults with COVID-19 and comorbidities.

Then, the non-parametric Kruskal-Wallis test compared ccf-mtDNA levels in the three groups, resulting in a highly significant statistical difference (p-value < 0.0001).

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When the median values of ccf-mtDNA in these two groups (4,649 × 7,769 ccf-mtDNA/mL) were compared by the Mann-Whitney test, the result did not reach statistical significance (p-value of 0.389) even though they were numerically different.

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