Indeed, 24-week-old SD-fed Mapk15 −/− male mice showed a diffuse increase of parenchymal echogenicity and echotexture heterogeneity, and frequent (43%) incidence of isoechoic appearance of the caudate liver lobe compared with the right kidney cortex (Supplemental Figure S3A, http://links.lww.com/HC9/C230 ), although differences in parametric values such as hepatorenal index (HRI) and liver echogenicity did not reach statistical significance (Supplemental Figures S3B, C, http://links.lww.com/HC9/C230 ).
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MAPK15 controls intracellular lipid uptake and protects mammalian liver from steatotic disease.
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