Longitudinal plasma proteomic signatures of elite and viremic spontaneous HIV controllers.

Nat Commun · 2026 · PMC12859116 · PMID 41571634

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hedged sentences

0.0800

closest p · 1.6× alpha

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boldest claim

The sentences

marginally significantP = 0.08so close (0.05 < p ≤ 0.1)

Additionally, CRTAM demonstrated a downregulation, although being marginally significant after FDR correction (log2 fold change = −0.57; FDR P = 0.08).

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did not reach statistical significanceno p-value reported

However, these trends did not reach statistical significance (Supplementary Fig. 7C ).

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a notable trendno p-value reported

While the exact reasons for ART initiation were not recorded, there was a notable trend of ART initiation around 2015, coinciding with the shift in guidelines that recommended ART for all PLHIV regardless of clinical stage, CD4 count or viral load levels.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.