Epigenetic memory as a readout of environmental susceptibility defines cell manufacturability in mesenchymal stem cell production.

Notably, under low-density culture, promoters of IDO-1 , IL-6 , ANG-1 , and COL-1 maintained relatively high K4/K27 ratios despite concurrent increases in H3K27me3 levels; in several cases, however, these observations did not reach statistical significance.

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