Normalized [ 18 F]FDG uptake in the MFG of both hemispheres decreased highly significant from baseline to follow-up PET in all patients (left MFG: mean reduction 10.7 ± 8.1%, FDR adjusted p = 0.002, right MFG: mean reduction 8.4 ± 4.1%, FDR adjusted p < 0.001) (see also Fig. 2 a; Table 2 ).
When combining both independently significant parameters in a multivariate logistic regression model, only MFG metabolism showed a trend toward significance ( p = 0.091), while age was not significant ( p = 0.812).
2 b-d) and did not reach statistical significance, though putamen and STN exhibited a trend-level effect (for details see Table 2 ).
Although at a statistical trend level only, this finding suggests that possible, pre-existing degeneration of the frontal lobe (as reflected by PET) could be a risk factor for neuropsychiatric SE after DBS surgery.