Drug Repurposing Screen Identifies Pimozide as a ROS-Inducing Therapy With Anti-Tumor Efficacy in HNSCC PDX Models.

Although this reduction did not reach statistical significance compared to paclitaxel monotherapy, fluorescence immunohistochemistry of PDX tumors revealed that undifferentiated tumor cells persisting after paclitaxel treatment were markedly reduced in the combination group (Figure 5C,D ).

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