Prognostic Impact of the Hevylite Assay in Patients With IgG or IgA Multiple Myeloma Treated Within the GMMG-MM5 Trial.

Again, high‐risk cytogenetics and ISS were found to be statistically significant prognostic factors both for PFS and OS, while HLCr normalization showed a trend for better PFS (HR 0.76, 95% CI 0.53–1.09, p = 0.13; Table 4 ) but not for OS (HR 0.90, 95% CI 0.49–1.65, p = 0.73; Table 5 ).

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Using a landmark analysis from the end of consolidation there was again a marginally statistically significant effect of HLCr normalization by the end of consolidation on PFS using a multivariable Cox model on the subset of the two study arms with continuous lenalidomide maintenance (HR 0.61, 95% CI 0.37–1.02, p = 0.06).

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