Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema.

CPT Pharmacometrics Syst Pharmacol · 2026 · PMC12862098 · PMID 41622599

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showed a trendno p-value reported

However, the objective function value was significantly worse (increase of 60), and eta versus covariate plots still showed a trend with body weight, as the effect of body weight on PK parameters was not fully described by the standard exponents.

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