Single-cell spatial transcriptomics uncovers niches that govern response to PD-1/PD-L1 blockade in cutaneous squamous cell carcinoma.

J Immunother Cancer · 2026 · PMC12863322 · PMID 41617396

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may be significantno p-value reported

Conversely, in the low antigen presentation myeloid niche, myeloid markers including TLR2, CLEC4A, and CSF1R are spatially co-expressed with T cell markers IL7R, TCF7, FYN, and TNFSF14, indicating there may be significant interfacing between myeloid cells and T cells in this niche ( online supplemental figure 4B ).

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showed a trendno p-value reported

Gene set enrichment analysis showed a trend of decreased interferon gamma response with increasing immunotherapy dose ( figure 5A1 ).

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