Mild Short-Term Caloric Restriction Induces Coordinated Changes That Promote Lipid Deposition While Maintaining Thermogenesis Capacity in Interscapular Brown Adipose Tissue of Male Rats.

D‐ribose 6‐phosphate tended to be reduced in iBAT from CR rats; however, the differences did not reach statistical significance (Figure 4C ). 3.4 CR Enhances Mitochondrial Respiration When Detected in Isolated Mitochondria but Not in Total Tissue Lysate Given the evidence that iBAT mitochondria are the principal site of thermogenesis, we investigated the ability of CR to affect their functionality by integrating western blot, proteomics, immunohistochemistry, and respirometry data.

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