Identification and characterization of tryptophan metabolism-related genes in carotid artery plaques.

Although no cell type reached statistical significance after FDR correction ( Fig 5E ; S5 Table ), endothelial cells, fibroblasts, and smooth muscle cells showed decreasing proportions in plaques, whereas macrophages and dendritic cells exhibited an increasing trend.

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Although the P-value of the enrichment analysis for the tryptophan metabolic pathway did not reach statistical significance (p.adj.value = 0.97), based on the standardized enrichment score (NES), it could be observed that this pathway showed an upregulation trend in plaque tissues (NES = 0.54).

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