Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B.

Although tri-SNP-101 trended towards protection against GADA-first outcome, this effect did not reach statistical significance either in the entire dataset (HR = 0.87, CI = 0.64–1.17, p =0.34, Figure 1D , Figure 1—figure supplement 5 , Supplementary file 1E ) or in DR3-DQ2 homozygotes (HR = 0.71, CI = 0.47–1.07, p =0.10, Figure 1D , Figure 1—figure supplement 6 , Supplementary file 1F ).

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