A retrospective comparative study of tenofovir alafenamide and tenofovir disoproxil fumarate in chronic hepatitis B patients: Renal and bone safety versus antiviral efficacy.

Medicine (Baltimore) · 2026 · PMC12863897 · PMID 41630254

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.2190

boldest claim

The sentences

a nonsignificant trendP = .058so close (0.05 < p ≤ 0.1)

Alanine aminotransferase normalization showed a nonsignificant trend favoring TAF at 12 months (73.08% vs 88.00%; P = .058).

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did not reach statistical significanceP = .219not close (p > 0.1)

New or worsening proteinuria occurred less frequently in the TAF group at 6 months (3.85% vs 16.00%; P = .039), and although the 12-month difference did not reach statistical significance (9.62% vs 18.00%; P = .219), the trend remained consistent.

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