Efficacy and Safety of Melatonin in Migraine Prophylaxis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Curr Pain Headache Rep · 2026 · PMC12864225 · PMID 41627537

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a favorable trendno p-value reported

However, there was a favorable trend toward melatonin (MD = −4.70 [95% CI: −9.90 to 0.50] for episodic migraine, and − 5.60 [95% CI: −13.32 to 2.12] for chronic migraine) (supplementary Fig. 3 ).

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did not reach statistical significanceno p-value reported

Other outcomes, such as improvements in the PSQI and MIDAS, were also noted, though they did not reach statistical significance.

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