Distinct alterations of adiponectin, fibroblast growth factor 21 (FGF-21), and insulin-like growth factor binding protein 2 (IGFBP-2) link dysmetabolism with cognitive decline across the Alzheimer's disease spectrum.

Alzheimers Dement · 2026 · PMC12865228 · PMID 41630588

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highly significantno p-value reported

As expected, we observed highly significant reciprocal correlations between serum FGF‐21, IGFBP‐2, and adiponectin.

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did not reach statistical significanceno p-value reported

A similar trend was found between IGFBP‐2 and serum levels of pTau231 and pTau217, but this association did not reach statistical significance (Figure 4A ).

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