Single-cell analysis reveals neuroprotective histone deacetylase inhibitor pathways.

When comparing TSA alone to control, a substantial 86.4% increase in DISC1 expression was observed (log 2 FC = 0.90, 1.86‐fold), though this did not reach statistical significance after Bonferroni correction for multiple comparisons (adjusted p = 0.079) (Figure 6B ).

also in 111,027 other papers

The top drug candidate identified was CGP‐60474, with a drug therapeutic score of 2.43 and highly significant FDR values, showing broad activity across neuronal and glial cell types.

also in 132,142 other papers