KRAS-ERK signaling drives metastasis in colorectal cancer via phosphorylation-dependent activation of the ZBTB20-TGFBR2 axis.

J Exp Clin Cancer Res · 2026 · PMC12865998 · PMID 41485060

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0.0900

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0.0900

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showed a trendp = 0.09so close (0.05 < p ≤ 0.1)

While high TGFBR2 expression showed a trend towards poorer overall survival ( p = 0.09), it was a significant predictor of worse disease-free survival ( p = 0.0063) (Supplemental Figure S4A, B).

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