Development and multicenter external validation of an intratumoral and peritumoral ultrasound-based radiomics model for preoperative prediction of HER2 status in IHC 2 + breast cancer.

Eur J Med Res · 2025 · PMC12866444 · PMID 41462365

Europe PMC DOI

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0.0010

closest p · 0.0× alpha

0.1000

boldest claim

The sentences

highly significantp < 0.001actually significant

In the training cohort, the HER2-positive group differed significantly from the HER2-negative group in age, LN metastasis, ER status, PR status, and Ki-67 (all p < 0.05), with age and Ki-67 showing highly significant differences ( p < 0.001).

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did not reach statistical significancep = 0.10so close (0.05 < p ≤ 0.1)

Compared with the radiomics model, the AUCs were numerically higher in both external validation cohorts, but the DeLong test did not reach statistical significance ( p = 0.10 and 0.20).

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