Retinal biomarkers in schizophrenia spectrum disorders: evidence and implications for the neurodevelopmental and neurodegenerative models.

A study comparing OCT indices between FEP patients with schizophrenia (with acute symptoms with a duration of less than 3 months and a total duration of illness of less than 5 years) and age- and sex-matched controls found that macular thickness and pRNFL thickness were reduced in FEP patients relative to controls (although the reduction in pRNFL thickness did not reach statistical significance) ( 199 ).

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