NUDT21-mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression.

In contrast, the effect of simvastatin on Nudt21 ‐knockdown tumors was modest and failed to reach statistical significance, further demonstrating the involvement of cholesterol in tumor immunosuppressive reprogramming (Figure 4H–K ).

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