Barely Significant
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Alpha-2 Adrenergic Agonists Reduce Heavy Alcohol Drinking and Improve Cognitive Performance in Mice.

eNeuro · 2026 · PMC12866760 · PMID 41513468

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a strong trendp = 0.059so close (0.05 < p ≤ 0.1)
As shown in Figure 6 B , when looking at the total number of cells expressing DeltaFosB in the LC, the two-way ANOVA showed a strong trend (n.s.) for an effect of alcohol, which was again independent from sex (Ethanol: F (1,28) = 3.87, p = 0.059, n.s.; Ethanol × Sex: F (1,28) = 0.69, p = 0.41, n.s.); when sexes were pooled together, IA2BC overall caused a 35.6% increase in LC cells expressing DeltaFosB (Student's t test: t (30) = 2.09, p ≤ 0.05).

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