Posttranscriptional regulation of PD-1 by PRMT5/WDR77 complex shapes T cell effector function and antitumor immunity.

FACS assays showed that ex vivo stimulation of CD8 + T cells purified from Prmt5 CKO and Wdr77 CKO mice elevated cell death and decreased amounts of CD44, Ki-67, granzyme B (Gzmb), and cytokines, which showed a trend toward partial restoration upon PD-1 blockade ( Figure 4, I–T , and Supplemental Figure 13 , E–G).

also in 53,322 other papers