Effectiveness of melatonin supplementation for improving sleep quality and disease severity in children with atopic dermatitis: a systematic review and meta-analysis.

Front Med (Lausanne) · 2025 · PMC12867768 · PMID 41647028

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closest p · 6.0× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.30not close (p > 0.1)

The pooled mean difference favored melatonin but did not reach statistical significance (MD − 3.86, 95% CI − 11.10 to 3.38; Z = 1.04, p = 0.30), with high heterogeneity (I 2 = 78%; Figure 5 ), and did not reach the MCID of 8.7 points for total SCORAD ( 15 ).

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