A monocyte-derived blood transcriptomic signature reveals systemic immunosuppression in HCC and partial reversal following curative therapy.

Front Immunol · 2025 · PMC12867797 · PMID 41646974

Europe PMC DOI

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0.1390

closest p · 2.8× alpha

0.1390

boldest claim

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showed a trendp = 0.139not close (p > 0.1)

Additionally, a multivariable Cox regression analysis showed a trend toward association with poorer overall survival (HR = 1.695, 95% CI: 0.842–3.414, p = 0.139), with several individual genes such as RNF24 (HR = 1.887, CI: 1.378–2.583, P = 7.55 × 10 −5 ) and CEP170 (HR = 1.681, CI: 1.147–2.465, P = 7.55e × 10 −3 ) being independently associated with prognosis ( Figure 6D ).

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