Molecular driving force of a small molecule-induced protein disorder-order transition.

Commun Chem · 2026 · PMC12867982 · PMID 41535595

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showed a trendno p-value reported

In WT MDM2, residues 12–16 showed a trend towards negative secondary 13Ca chemical shifts upon AM-7209 addition, while residues 20–23 showed a trend towards positive 13Ca chemical shifts (Fig. 4E , light purple and purple), consistent with increased β-strand and α-helical propensity, respectively.

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