Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition.

J Adv Res · 2026 · PMC12869262 · PMID 40288675

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Consistent with previous studies of inflammation-related diseases, the expression of DEL-1 showed a trend of down-regulation followed by up-regulation from the initiation of inflammation to its resolution in IBD patients, colitis mice, and macrophages [ 15 , 18 ].

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