Differences in microRNA levels across metabo-endotypes reveal novel insights into asthma heterogeneity.

For instance, miR-143-3p showed a nominally significant positive correlation with hippurate, a gut microbiota-derived polyphenol metabolite previously associated with asthma [ 5 ], in individuals from metabo-endotype 2, while a negative correlation was observed in those from metabo-endotype 3.

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The comparison between metabo-endotype 2 and 3 accounted for 141 (28.2%) of the 501 FDR significant hits and QQ-plots demonstrate that there was an enrichment of highly significant findings in metabo-endotypes 2 and 3, relative to the others (Fig. 3 a).

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