Barely Significant
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Association between cannabis consumption and serum Klotho levels in middle-aged U.S. adults: NHANES cross-sectional analysis.

J Cannabis Res · 2026 · PMC12870139 · PMID 41495871

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a significant trendno p-value reported
Frequent users had significantly lower Klotho than never users (adjusted Estimate = -57.94, P = 0.027), with a significant trend ( P for trend = 0.022).

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