U-shaped association between TC/HDL-C ratio and the risk of metabolic dysfunction-associated fatty liver disease in older adults.

Notably, the association was slightly attenuated in individuals with a history of stroke (OR = 1.40, 95% CI 0.95–1.98) compared with those without (OR = 1.86, 95% CI 1.66–2.10), with a marginally significant interaction ( p = 0.046).

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When the ratio was analyzed in quartiles, a significant trend was observed ( p for trend = 0.049), though the association for the highest quartile (Q4) was no longer statistically significant in the fully adjusted model (OR 1.36, 95% CI 0.86–2.13, p = 0.17).

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