AAV-mediated multiple gene therapy combining VEGFA-targeting miR-agshRNAs and PEDF for the suppression of choroidal neovascularization.

Mol Ther Nucleic Acids · 2026 · PMC12870476 · PMID 41646887

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 0.0001actually significant

Quantification of GS-IB4 and CD31 CNV area demonstrated a highly significant reduction in the median lesion area of 45.6 [27.1–59.4]% ( p = 0.0001) and 45.1 [24.3–60.2]% ( p = 0.0006), respectively, in 13-12AB-PEDF-injected eyes compared with S1-S2AB-AsRed-injected control eyes ( Figures 5 B–5D).

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a strong trendno p-value reported

44 In this study, we showed a strong trend toward an additive effect of PEDF upregulation and Vegfa knockdown on neovessel formation.

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