O-GlcNAc transferase couples nutrient availability to synaptic plasticity in paraventricular neurons to regulate satiety.

The comparison of decay tau fold-changes between the groups showed a trend toward significance (WT: 0.87 ± 0.16; OGT-KO: 1.05 ± 0.09; p = 0.053), although it did not reach the conventional threshold for statistical significance ( Fig. 4 K ).

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In contrast, OGT-KO neurons exhibited an opposite trend, with feeding resulting in more than a two-fold lower sEPSC frequency than in the hungry state, although this difference did not reach statistical significance (OGT-KO hungry: 1.45 ± 1.08 Hz; OGT-KO fed: 0.59 ± 0.50 Hz; p = 0.095) ( Fig. 3 P ).

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