Sex-specific nonlinear DNA methylation aging trajectories reveal biomarkers of cancer risk and inflammation.

Genome Biol · 2026 · PMC12870970 · PMID 41634811

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hedged sentences

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closest p · 4.4× alpha

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boldest claim

The sentences

highly significantp value < 2.2 × 10− 1not close (p > 0.1)

The analysis revealed a highly significant association (χ 2 = 403,770, df = 16, p value < 2.2 × 10− 1 6), indicating that CpGs were classified into the same trajectory category in both sexes more frequently than expected by chance.

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mildly significantno p-value reported

3 C), and the female NL11 cluster as mildly significant.

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