CRISPR-Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl-fumarate-induced cell death.

FEBS J · 2026 · PMC12871913 · PMID 40748748

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failed to reach statistical significanceno p-value reported

Consequently, the sensitizing effects of PRC2 inhibition were also significantly diminished in both cell lines and failed to reach statistical significance in several conditions.

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highly significantno p-value reported

Moreover, in conjunction with DMF, it induces a highly significant increase in cell death.

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