Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation.

In these neighbourhoods, we assessed disease-protein enrichment using Open Targets, aggregated nominally significant associations at the strain level, and summarized them by disease group (Fig. 4c and Supplementary Data 23 ).

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Random sampling demonstrates highly significant effector convergence on few host interactors (Fig. 2h ), a phenomenon linked to the functional importance of the targeted host proteins as shown in plant–pathogen systems 13 .

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