Immunophenotyping TCF1-expressing TILs: spatial profiling and prognostic value in operable non-small cell lung cancer.

Front Immunol · 2026 · PMC12872492 · PMID 41659881

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closest p · 1.1× alpha

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a strong trendp=0.055so close (0.05 < p ≤ 0.1)

As TCF1 was also expressed by cancer cells, we assessed its prognostic impact and found that increased percentage of TCF1 + in cancer cells was associated with a strong trend for a worse DFS in the TC (HR:2.5, 95%CI:1.0-6.5 p=0.055), a trend that became significant when the TCF1 positivity was assessed in the IF (HR:2.1, 95%CI:1.0-4.4, p=0.045) ( Table 1 , Figure 1D ).

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a statistical trendno p-value reported

Unexpectedly, high levels of CD8 + TCF1 + cells revealed a statistical trend towards worse DFS in the TC ( Figures 1B, C , Table 1 ).

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