Barely Significant
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Real-World Effectiveness and Safety of Tildrakizumab in Moderate-to-Severe Psoriasis: A Multicenter Experience in the Basque Country.

Dermatol Ther (Heidelb) · 2026 · PMC12873055 · PMID 41350513

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hedged sentence
0.0900
closest p · 1.8× alpha
0.0900
boldest claim

The sentences

did not reach statistical significancep = 0.09so close (0.05 < p ≤ 0.1)
While the numerical differences between groups ranged from 14 to 21 percentage points across timepoints, these differences did not reach statistical significance (week 28: p = 0.09, week 52: p = 0.12, week 76: p = 0.67; chi-squared test), likely owing to the relatively small number of bio-naïve patients ( n = 26 at week 28, n = 19 at week 52, n = 6 at week 76) and the robust efficacy observed in both subgroups.

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