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Optimal murine CD4<sup>+</sup> T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing.

Nat Commun · 2026 · PMC12873236 · PMID 41545353

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showed a trendno p-value reported
Mice immunized with hematopoietic-depleting HA-miR142t mRNA-LNPs showed a trend towards lower frequencies of Tfh cells and had significantly fewer total Tfh cells in the draining lymph nodes nine days p.i.

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