Structural brain alterations in anorexia nervosa: a global brain volume and anatomical likelihood estimation (ALE) meta-analysis combined with a functional decoding approach.

Conversely, a nominally significant positive association was detected for the term “action”, indicating that brain areas associated with this term seem to be especially affected by volume reductions (nominal p < 0.05). 3.4.2 Spatial associations with neurotransmitter systems The spatial colocalization analyses with neurotransmitter atlases indicated a nominally significant negative association between the ALE map of the analysis “GM_loss_acute” and the distribution of serotonin transporters (5-HTT) (nominal p < 0.05; Fig. 4D , Supplementary Table 11 ).

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Highly significant brain volume changes for all three compartments (GM, WM, and CSF) were found in acutely ill patients with AN ( Supplementary Fig. 1A–C ).

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