Prevalence and risk factors of metabolic syndrome in survivors of childhood acute leukemia: a systematic review and meta-analysis.

Five studies evaluated cranial radiation therapy (CRT) as a risk factor for MetS, with three case–control studies showed a borderline non-significant association (OR: 1.79, 95% CI: 1.00–3.20, P = 0.050), while cohort studies identified it as a significant risk factor (RR: 1.72, 95% CI: 1.22–2.41, P = 0.002).

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The pooled analysis of case–control studies showed a borderline significant association (pooled OR: 1.79, 95% CI: 1.0–3.20, P = 0.050), a result that is likely underpowered to detect a true effect.

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