TNKS1 mediates the PTEN-PI3K/AKT pathway to regulate glycolysis and proliferation in gliomas.

PI3K agonist or inhibitor treatment further corroborated this trend, although inter-group differences did not reach statistical significance in a few comparisons. qPCR analyses subsequently revealed that TNKS1 silencing markedly reduced GLUT1 and HK2 mRNA levels, while TNKS1 over-expression up-regulated both transcripts; accordingly, agonist exposure elevated GLUT1/HK2 transcription and inhibitor exposure reduced it.

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