Relationship between estimating glomerular filtration rate and cerebral large artery stenosis: a secondary analysis of a cross-sectional study.

Front Med (Lausanne) · 2026 · PMC12875958 · PMID 41658596

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.1050

boldest claim

The sentences

a decreasing trendP < 0.001actually significant

The average age showed a decreasing trend from T1 to T3 (68.25 ± 8.21, 63.51 ± 8.65, and 60.74 ± 8.90 years, respectively; P < 0.001).

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borderline significantP = 0.051so close (0.05 < p ≤ 0.1)

Notably, we observed a borderline significant effect modification by sex (interaction P = 0.051), with women showing a stronger inverse association (OR = 0.98, 95% CI: 0.96–0.99), while no significant association was found in men (OR = 1.00, 95% CI: 0.99–1.02).

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did not reach statistical significanceP = 0.105not close (p > 0.1)

Additionally, although the interaction did not reach statistical significance (interaction P = 0.105), the inverse association between eGFR and LCAS was more pronounced in statin users (OR = 0.97, 95% CI: 0.95–0.99) compared to non-users (OR = 0.99, 95% CI: 0.98–1.01).

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