<i>CMTM8</i> variants influence BNT162b2 COVID-19 vaccination response by regulating granulocytic/polymorphonuclear myeloid-derived suppressor cell activity.

Interestingly, a nominally significant association was observed between rs7643677 and the trait “disease severity” in the COVID-19 Host Genetics Initiative study ( 14 ), with its C allele associated with a higher risk of developing severe symptoms or conditions that typically require hospitalization (effect size = 0.026, p -value=6.48×10 -3 ).

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